Xenoblade Chronicles by Monolith Soft is being localized for North America - I guess technically we're getting a European version but that makes it more awesome because of all the excellent British voice acting. The game takes place on the bodies of two huge giant god things. Ya, we're not on a sphere or a planet or Earth or any of that nonsense. You are standing on a dead god thing! It's actually really wicked to see a huge hand in the background of the world and know you could go stand on it.
The story apparently starts off really default, orphaned boy, destined hero, etc., but I've read it has lots of twists and the story is amazing. Graphics look great, remember it is the wii though so I'm talking "wii great." Environment is amazing, battle system looks fun, and it just looks like a blast. I'll totally be getting a copy when it hits the store shelves this April.